General Information

  • ID:  hor004494
  • Uniprot ID:  P84489
  • Protein name:  Somatostatin-25
  • Gene name:  NA
  • Organism:  Anguilla anguilla (European freshwater eel) (Muraena anguilla)
  • Family:  Somatostatin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Anguilla (genus), Anguillidae (family), Anguilliformes (order), Elopomorpha, Elopocephala, Elopocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SVDNQQGRERKAGCKNFYWKGPTSC
  • Length:  25(1-25)
  • Propeptide:  SVDNQQGRERKAGCKNFYWKGPTSC
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  inhibit the release of somatotropin
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P84489-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P84489-F1.pdbhor004494_AF2.pdbhor004494_ESM.pdb

Physical Information

Mass: 328843 Formula: C121H187N39O38S2
Absent amino acids: HILM Common amino acids: GK
pI: 9.46 Basic residues: 5
Polar residues: 11 Hydrophobic residues: 4
Hydrophobicity: -140.8 Boman Index: -7935
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 15.6
Instability Index: 2080 Extinction Coefficient cystines: 7115
Absorbance 280nm: 296.46

Literature

  • PubMed ID:  2904391
  • Title:  Somatostatin-related and Glucagon-Related Peptides With Unusual Structural Features From the European Eel (Anguilla Anguilla)